Tim-KGS,
There is no built-in method to change a file permission. LANDesk will get you 90% of the way there by being your framework to make the change - but it will require you to either user a script package or manage scripts to get the last 10%.
echo Y | C:\Windows\System32\CACLS.exe "%ProgramFiles%\Application Folder\Application.exe" /R "users" /E /T
*Note: Change the group name as needed.
Your primary two options:
Add that as a batch file and create a distribution package for it - which you can deploy as a policy or push.
Add that as a manage script - which you can deploy as a scheduled push or push.
An advanced method for Desired State Configuration would be to setup a custom definition in LANDesk that checked the folder/file permissions then set your desired permissions if they are not already there. This way it keeps them in compliance.
Hope this helps to clarify your question,
Peter