What I have found that works is these setting. Mail and Web had no change so with them on or off does not matter.
I have been having the same issues. Once I shutoff System Watcher in the config the computer was usable again.
I have provided support with Log files as well as reached out to Kasperskey as this was and issue that was common in there native av engine. Issue is the av engine is behind it is running at 10.2.1.23 (a)