The answer is No and Yes. It is not natively possible within SD, but you could do it with a little work outside of SD.
- Create a script (in VBA) or Application (in Visual Studio, etc.) that appends the Sender's address to the beginning of the message's Subject. Something like:
Item.Subject = "[supportSAP@yourcompany.com] " + Item.Subject - Create a rule on your mailbox in Exchange that runs against all messages that arrive.
If using a script, choose the action "Run a script". If using a custom application, choose "Start application". - Have conditions in your Workflow that check this updated Subject line and route it accordingly. You may also want your process to strip out the email address from your updated subject, just to return it to normal.
I'm also looking at a Powershell script that you could run on your Exchange server to replace the rule/script part, will let you know if anything comes of it.
-Brian