Hi TF,
the "Never Reboot" option can only prevent reboots from things LANDESK is involved in. The MSI is executed from the Microsoft Installer and LANDESK has no influence on this behavior. Same would be if you create a package with a shutdown.exe, this shutdown will happen whatever you configure in your agent settings.
Lets say you set the "Never reboot" option but for one special software task you choose a reboot setting with the option "Act as if reboot is ALWAYS needed" or "Detect whether reboot is needed". These setting will be overwritten by the "Never reboot" flag and the client will not reboot.
Hope that helps.
Regards
Christian